Orthopedic Infections (Bone & Joint)

The Problem

Orthopedic and post-surgical infections are among the most serious complications following trauma or surgery.
They often occur after fracture fixation (e.g., hip or femoral neck fractures) or joint replacements, where internal implants and poor blood circulation create an ideal environment for bacterial colonization and biofilm formation.

Such infections lead to:

  • Prolonged hospitalizations
  • Repeated debridement or revision surgeries
  • Loss of bone integrity and delayed fracture healing
  • Functional disability and chronic pain

Systemic antibiotics frequently fail to penetrate bone or implant surfaces at therapeutic concentrations. Biofilms protect bacteria from both antibiotics and immune responses, making eradication extremely challenging.

The GentaGel™ Solution

  • High, sustained antibiotic levels directly in bone or soft tissue – maintains effective concentrations for up to 60 days.
  • Biofilm penetration – locally delivered antibiotics reach bacteria that systemic therapy cannot.
  • Injectable & Biodegradable – no need for removal, fits complex bone cavities or implant sites.
  • Prevention & Treatment – suitable both for infected fixation sites and prophylactic use during revision surgery.
  • Faster recovery & shorter hospitalization – minimizes recurrence and facilitates earlier rehabilitation.

Market Impact (U.S.)​

~1.4M

Annual Surgeries In the U.S. market

~25K

Infections resulting in revisional surgery

~15.5%

Will need more procedures

~$1.5B

The total healthcare costs of these infections is in the U.S. market